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Selected Publications by Founder, Dr. Eunice Yu Zhou

1.      Yu Zhou, Hao Zou, Christina Yau, Lequn Zhao, Steven C. Hall, Daryl C. Drummond, Shauna Farr-Jones, John W. Park, Christopher C. Benz, James D Marks. Discovery of internalizing antibodies to basal breast cancer cells. Protein Eng Des Sel. 2018 Jan 1;31(1):17-28. doi: 10.1093/protein/gzx063. PMID: 29301020

2.      Le Gall M, Crépin R, Neiveyans M, Auclair C, Fan Y, Zhou Y, Marks JD, Pèlegrin A, Poul MA. Neutralization of KIT Oncogenic Signaling in Leukemia with Antibodies Targeting KIT Membrane Proximal Domain 5. Mol Cancer Ther. 2015 Nov;14(11):2595-605. doi: 10.1158/1535-7163.MCT-15-0321. Epub 2015 Sep 10. PMID: 26358753

3.      Li K, Zettlitz KA, Lipianskaya J, Zhou Y, Marks JD, Mallick P, Reiter RE, Wu AM. A fully human scFv phage display library for rapid antibody fragment reformatting. Protein Eng Des Sel. 2015 Oct;28(10):307-16. doi: 10.1093/protein/gzv024. Epub 2015 May 19. PMID: 25991864

4.      TA Seldon, R Pryor, A Palkova, ML Jones, ND Verma, M Findova, K Braet, Y Sheng, Y Fan, EY Zhou, JD Marks, T Munro, SM Mahler, RT Barnard, PD Fromm, PA Silveira, Z Elgundi, X Ju, GJ Clark, KF Bradstock, DJ Munster and DNJ Hart. Immunosuppressive human anti-CD83 monoclonal antibody depletion of activated dendritic cells in transplantation. Leukemia, 2015, 1-9. PMID: 26286117

5.      Zhao L, Qu L, Zhou J, Sun Z, Zou H, Chen YY, Marks JD, Zhou Y. High throughput identification of monoclonal antibodies to membrane bound and secreted proteins using yeast and phage display.  PLoS One. 2014 Oct 29;9(10):e111339. doi: 10.1371/journal.pone.0111339. eCollection 2014. PMID: 25353955

6.      Jones AR, Stutz CC, Zhou Y, Marks JD, Shusta EV. Identifying blood-brain-barrier selective single-chain antibody fragments.  Biotechnol J. 2014 May; 9(5):664-74. PMID: 24644233

7.      Zhou Y, Zhao L, Marks JD. Selection and characterization of cell binding and internalizing phage antibodies. Archives of Biochemistry and Biophysics, 2012 May (Epub ahead of print) PMID:22627065

8.      Zhou Y, Goenaga AL, Harms B, Zou H, Lou J, Conrad F, Adams GP, Schoeberl B, Nielson UB, Marks JD. Impact of intrinsic affinity on functional binding and biological activity of EGFR antibodies.  Mol. Can. Ther. 2012 Jul;11(7):1467-76  PMID: 22564724

9.      Yu Zhou, Hao Zou; Shaoyi Zhang; James D Marks. Internalizing cancer antibodies from phage libraries selected on tumor cells and yeast displayed tumor antigens. J. Mol. Biol. 2010 Nov 19; 404(1): 88-99. PMCID: 20851130

10.    Lepin EJ, Leyton JV, Zhou Y, Olafsen T, Salazar FB, McCabe KE, Hahm S, Marks JD, Reiter RE, Wu AM. An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors. Eur. J. Nucl. Med. Mol. Imaging (2010) Aug;37(8):1529-38. Epub 2010 Apr 1. PMID: 20354850

11.    Yu Zhou, Daryl C. Drummond, Hao Zou, Mark E. Hayes, Gregory P. Adams, Dmitri B. Kirpotin, James D. Marks. Impact of single chain Fv antibody fragment affinity on nanoparticle targeting of epidermal growth factor receptor expressing tumor cells. J. Mol. Biol. (2007) 371, 934-947

12.    Anne-Laure Goenaga1, Yu Zhou1, Christine Legay, Lan Huang, Bin Liu, Daryl C. Drummond, Dmitri B. Kirpotin, Christian Auclair, James D. Marks, Marie-Alix Poul. Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies. Molecular Immunology. (2007) 44(15), 3777-3788

Book Chapters by Founder, Dr. Eunice Yu Zhou

1.   Yu Zhou, James D Marks. Mechanism of action for therapeutic antibodies. Biosimilars of Monoclonal Antibodies: A Practical Guide to Manufacturing, Preclinical and Clinical Development, 2016, Chapter 3, ISBN: 978-1-118-66231-1

2.   Zhou Y, Marks JD. Discovery of internalizing antibodies to tumor antigens from phage libraries. Methods Enzymol. 2012;502:43-66.PMID:22208981

3.   Yu Zhou, James D Marks. Selection of phage antibody libraries for binding and internalization into mammalian cells. Antibody Engineering, 2010, Vol.1, Chapter 13.

4.   Consuelo Gracia-Rodriguez, Yu Zhou, James D Marks. Antibody epitope mapping using yeast display. Antibody Engineering, 2010, Vol.1, Chapter 37.

5.   Yu Zhou, James D Marks. Identification of target and function specific antibodies for effective drug delivery. Methods in Molecular Biology, 2009; 525: 145-60, xv.